Abstract
Three condensed aromatic peptides SCH79235 (1), SCH79236 (2), and SCH204698 (3) were isolated from the fermentation broth of a Streptomycete microorganism. The structure of SCH204698 (3) was established by extensive NMR spectral data. All these compounds exhibited good activity against CD28-CD80 binding with an IC(50) of 0.42, 0.38 and 0.22 microM, respectively.
MeSH terms
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B7-1 Antigen / drug effects*
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Binding, Competitive / drug effects
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CD28 Antigens / drug effects*
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Chlorophenols / chemistry
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Chlorophenols / pharmacology
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Fermentation
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Magnetic Resonance Spectroscopy
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Peptides / isolation & purification*
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Peptides / pharmacology*
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / isolation & purification*
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Peptides, Cyclic / pharmacology*
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Spectrometry, Mass, Fast Atom Bombardment
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Spectrophotometry, Ultraviolet
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Streptomyces / metabolism*
Substances
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B7-1 Antigen
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CD28 Antigens
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Chlorophenols
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Peptides
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Peptides, Cyclic
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SCH204698
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SCH79235
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SCH79236
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chloropeptin I
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complestatin