Condensed aromatic peptide family of microbial metabolites, inhibitors of CD28-CD80 interactions

Bioorg Med Chem Lett. 2003 Feb 10;13(3):573-5. doi: 10.1016/s0960-894x(02)00919-8.

Abstract

Three condensed aromatic peptides SCH79235 (1), SCH79236 (2), and SCH204698 (3) were isolated from the fermentation broth of a Streptomycete microorganism. The structure of SCH204698 (3) was established by extensive NMR spectral data. All these compounds exhibited good activity against CD28-CD80 binding with an IC(50) of 0.42, 0.38 and 0.22 microM, respectively.

MeSH terms

  • B7-1 Antigen / drug effects*
  • Binding, Competitive / drug effects
  • CD28 Antigens / drug effects*
  • Chlorophenols / chemistry
  • Chlorophenols / pharmacology
  • Fermentation
  • Magnetic Resonance Spectroscopy
  • Peptides / isolation & purification*
  • Peptides / pharmacology*
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / isolation & purification*
  • Peptides, Cyclic / pharmacology*
  • Spectrometry, Mass, Fast Atom Bombardment
  • Spectrophotometry, Ultraviolet
  • Streptomyces / metabolism*

Substances

  • B7-1 Antigen
  • CD28 Antigens
  • Chlorophenols
  • Peptides
  • Peptides, Cyclic
  • SCH204698
  • SCH79235
  • SCH79236
  • chloropeptin I
  • complestatin